STENA-STER (SR 9009 – STENABOLIC)

 ACTIVE HALF LIFE 24 HOURS
 CLASSIFICATION SARM
 CONCENTRATION 60 CAPSULES@15MG/CAP
CAS NUMBER 1379686-30-2
 PURITY 99%
 FORMAT CAPSULE
ORAL AVAILABILITY HIGH
 RELATED SUBSTANCE OSTARINE, ANDARINE, TESTOLONE
 LEGAL STATUS RESEARCH/LABORATORY CHEMICAL

Description

SR9009, also known as Stenabolic, is a selective androgen receptor modulator (SARM) that has been referred to as ‘exercise in a bottle’. Initial trials on mice showed an increase in muscle and metabolic rate without exercise, and enhanced stamina with exercise. Essentially, SR9009 has shown promise to improve endurance and metabolism to become leaner.

How It Works?

The compound SR9009 works by binding to one of the body’s naturally occurring molecules, called Rev-Erbα. This molecule influences lipid and glucose metabolism in the liver, the production of fat-storing cells, and the response of macrophages (cells that remove dead or dying cells) during inflammation.

The study showed that mice lacking Rev-Erbα had decreased muscle metabolic activity and running capacity. However, Burris’ group demonstrated that activation of Rev-Erbα using Stenabolic led to increased metabolic activity in skeletal muscle in both culture and mice. The difference was a 50% increase in running capacity for mice treated with SR9009 – even when exercise was restricted.

Professor Burris explained that the study resulted in animals developing muscles just like an athlete who has been training, even when they haven’t. He believes that Rev-Erbα affects muscle cells through the creation of new mitochondria, and the removal of defective mitochondria via macrophages.

The Benefits of SR9009: A Drug Causing Major Breakthroughs

There are 7 primary benefits that have been observed in both initial studies and user-reported reviews.

  1. SR9009 increases weight loss

Stenabolic shows great promise in increasing weight loss, even without exercise – which is why it’s being touted as “exercise in a bottle”.

In initial studies, researchers chose mice with low skeletal muscle and metabolism to treat with SR9009. Over a 30-day study, the muscle and metabolic rate of the mice increased, even when they weren’t allowed to exercise.

Increased mitochondria activity was noted in muscle, as well as an increase in macrophages – cells that remove dying or dead cells – enhancing the energy output of the animal’s muscles to create athletic, oxidative muscle without any actual exercise.

Due to this increase in muscle activity, SR9009 helped the body burn calories instead of turning them into fat, effectively allowing an increase in weight loss.

  1. SR9009 increases stamina and endurance

Additional to muscle conditioning, initial studies showed that once the mice that were treated with Stenabolic for 30 days were allowed to exercise, they showed a 50% increase in endurance – running longer and covering more distance than controls.

This may be due to an increase in the glucose oxidation in skeletal muscle, allowing the body to go faster for longer with a higher level of strength and stamina.

  1. SR9009 may lower blood cholesterol

Mice treated with SR9009 for 7-10 days showed reduced blood levels of triglycerides and total cholesterol.

Another study suggested that targeting Rev-Erbα may be an effective method for suppressing LDL cholesterol levels using SR9009. Over an 8-week period, genetically modified mice with a similar fat profile to humans were treated with SR9009, resulting in significant decrease in total cholesterol, triglycerides, and LDL cholesterol.

  1. SR9009 indicates a decrease in inflammation

Stimulation of Rev-Erbα activity by SR9009 was shown to greatly diminish ventilator-induced lung edema and inflammatory cells in rats.

The study suggests that the circadian rhythm affects the immune response, which may exacerbate inflammation. As Rev-Erbα plays a role in regulating the circadian rhythm, SR9009 may help reduce inflammation by activating Rev-Erbα.

5. SR9009 may increase wakefulness

 Due to ist ability to activate Rev-Erbα, Stenabolic can affect the wakefulness of mice. As it affects the circadian rhythm, when SR9009 was injected into mice during periods they usually sleep, they were kept awake longer and had less REM sleep.

However, when the mice were injected with SR9009 during their normal awake hours, there was no perceptible change in their behaviour.

This suggests that Stenabolic may be useful for sleep-related disorders such as narcolepsy or shift workers.

  1. SR9009 may reduce heart disease

Studies show that both normal and genetically modified older mice had improved heart function when injected with SR9009. Mice with surgically-induced heart growth (hypertrophy) showed a reduction in heart size and weight without affecting their blood pressure after two weeks of treatment with SR9009.

  1. SR9009 may effectively reduce anxiety

Mice injected with SR9009 twice per day for 3 to 10 days showed decreased anxiety-like behavior. Interestingly, it has been suggested that SR9009 was as effective as a benzodiazepine, even though it shows potential to increase stamina and endurance of athletes.